Retinal neovascularization in the setting of <i>CALR</i>-mutation positive essential thrombocythemia

Patients with Calreticulin ( CALR) mutation positive essential thrombocythemia are often thought of as having a “low-risk” thrombotic complications. This report examines case patient CALR-mutation presenting peripheral retinal ischemia and subsequent neovascularization. had 2-year documented history maximum platelet count over 800,000 cells/µL. Fluorescein angiogram showed significant leakage in the areas vascular lesions nonperfusion consistent The was treated photocoagulation to avascular retina. At 6-month follow-up, some regression neovascularization noted no signs progression retinopathy. Furthermore, patients can present secondary due microvascular events. Identification these changes is important for guiding medical procedural interventions order preserve vision.